Figure 3.

UPR signalling and EMT in cancer. In response to diverse ER stressors, UPR signalling is activated to relieve the stress and favour survival. In some tumours, the ER stress sensors and signalling players PERK and IRE1 are proposed to modulate EMT by impinging on particular EMT-TFs. Through the implementation of EMT, UPR can contribute to the progression and recurrence of tumours upon treatment. Thus, ER stress and UPR components can be exploited as plausible targets for anti-cancer therapy.