Table 1.
Clinicopathologic characteristics of included patients.
| Characteristics | Total Number of Cases | eGPC3 | tGPC3 | ||||
|---|---|---|---|---|---|---|---|
| eGPC3 low | eGPC3 high | P-Value | tGPC3 low | tGPC3 high | P-Value | ||
| Age | |||||||
| < median = 63 years | 24 | 15 | 9 | 0.156 | 11 | 13 | 0.778 |
| ≥ median = 63 years | 25 | 10 | 15 | 13 | 12 | ||
| Gender | |||||||
| Male | 34 | 16 | 18 | 0.538 | 18 | 16 | 0.538 |
| Female | 15 | 9 | 6 | 6 | 9 | ||
| Classification of Lauren | |||||||
| Intestinal | 23 | 11 | 12 | 0.342 | 9 | 14 | 0.560 |
| Diffuse | 14 | 8 | 6 | 8 | 6 | ||
| Mixed | 5 | 1 | 4 | 2 | 3 | ||
| Missing | 7 | 5 | 2 | 5 | 2 | ||
| UICC stage | |||||||
| I and II | 37 | 18 | 19 | 0.742 | 20 | 17 | 0.321 |
| III and IV | 12 | 7 | 5 | 4 | 8 | ||
| Tumor size | |||||||
| T1 and T2 | 34 | 16 | 18 | 0.538 | 17 | 17 | 1.000 |
| T3 and T4 | 15 | 9 | 6 | 7 | 8 | ||
| Lymph node status | |||||||
| N0 and N1 | 39 | 9 | 15 | 0.089 | 20 | 19 | 0.572 |
| N2 and N3 | 10 | 16 | 9 | 4 | 6 | ||
| Metastasis status | |||||||
| M0 | 43 | 20 | 23 | 0.189 | 23 | 20 | 0.189 |
| M1 | 6 | 5 | 1 | 1 | 5 | ||
| Resection margin status | |||||||
| R0 | 43 | 20 | 23 | 0.189 | 22 | 21 | 0.667 |
| R1 and R2 | 6 | 5 | 1 | 2 | 4 | ||
| Tumor differentiation | |||||||
| G1 and G2 | 17 | 9 | 8 | 0.751 | 4 | 13 | 0.050 |
| G3 and G4 | 22 | 10 | 12 | 13 | 9 | ||
| CEA | |||||||
| < Median | 21 | 9 | 12 | 0.538 | 12 | 9 | 0.215 |
| > Median | 20 | 11 | 9 | 7 | 13 | ||
| CA 19-9 | |||||||
| < Median | 21 | 11 | 10 | 0.758 | 8 | 13 | 0.354 |
| > Median | 20 | 9 | 11 | 11 | 9 | ||
| CA 72-4 | |||||||
| < Median | 24 | 12 | 12 | 0.732 | 11 | 13 | 0.292 |
| > Median | 12 | 5 | 7 | 3 | 9 | ||
| Adjuvant therapy | |||||||
| Yes | 22 | 13 | 8 | 0.244 | 11 | 16 | 0.244 |
| No | 27 | 11 | 16 | 13 | 8 | ||
| Neoadjuvant therapyes | |||||||
| Yes | 27 | 16 | 11 | 0.256 | 9 | 13 | 0.393 |
| No | 22 | 9 | 13 | 15 | 12 | ||
Abbreviations: Glypican 3 (GPC3), tissue expression of GPC3 (tGPC3) and corresponding serum exosomes (eGPC3), carcinoembryonic antigen (CEA), carbohydrate antigen (CA), union of international cancer control (UICC). Significant p values are highlighted using bold font.