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. Author manuscript; available in PMC: 2020 Mar 27.
Published in final edited form as: J Am Chem Soc. 2019 Mar 12;141(12):5062–5070. doi: 10.1021/jacs.9b01784

Scheme 1.

Synthesis of a Key Tertiary α-Hydroxy Acid Intermediate.

Scheme 1.

aParenthetical data reflect results of an independent run for which intermediates were isolated, purified, and characterized. See the Supporting Information for details. bAfter recrystallization. See the Supporting Information for details.