Table 2.

Impact of sex and age on the circulating lipidome of 100 healthy individuals as revealed by supervised correlation analysis between identified groups of lipid subclasses and fatty acyl side chains (strategy 2).

				P-value/correlation
				PC1	PC2	PC1	PC2
Category	Subclass	Features #	Unique lipids #	Sex		Age
FA	FFA	13	12	1E-02/−0.27	6E-01/0.04	1E-02/0.25	1E-01/0.15
GP	LPC	73	37	2E-01/−0.14	8E-02/0.18	8E-01/0.07	8E-01/0.02
	LPCO-	3	3	2E-01/−0.13	9E-01/0.00	9E-01/0.02	1E-01/−0.16
	LPE	22	8	6E-01/0.07	5E-01/−0.08	1E-01/−0.16	4E-02/0.21
	PC	129	75	6E-02/−0.18	5E-01/−0.08	1E-01/−0.15	1E-01/0.15
	PCO-	35	27	5E-01/0.09	3E-01/−0.09	1E-02/−0.26	4E-01/−0.07
	PE	14	8	4E-02/−0.21	2E-2/0.25	4E-01/−0.08	2E-03/−0.30
	PI	8	8	6E-02/−0.18	6E-01/0.03	2E-01/−0.13	3E-06/0.28
SP	SM	55	29	1E-01/−0.18	1E-01/0.14	3E-01/0.10	4E-02/0.21
	Cer	25	9	2E-02/0.23	5E-01/−0.08	1E-01/0.16	2E-01/0.13
	Glc-Cer	6	6	8E-01/−0.02	8E-4/−0.34	4E-01/−0.09	1E00/−0.16
ST	CE	25	7	1E-01/−0.15	3E-01/−0.13	9E-01/0.02	6E-3/0.28
GL	DG	5	4	1E-02/0.25	2E-01/0.16	3E-01/0.10	1E-2/0.26
	TG	72	62	3E-04/0.36	4E-01/−0.09	9E-01/−0.01	7E-01/−0.04
Fatty acyls		Features #	Unique lipids #	Sex		Age
C18:2		92	53	9E-01/−0.02	2E-02/0.25	3E-06/−0.45	9E-01/−0.02
C20:4		75	45	8E-01/−0.02	2E-01/0.13	8E-01/−0.02	5E-01/−0.07
C20:5		15	9	1E-01/−0.18	1E-03/0.33	9E-02/−0.02	4E-01/−0.09
C22:4		10	8	5E-02/0.19	5E-02/−0.20	2E-01/0.14	9E-01/−0.01
C22:5		11	9	6E-01/0.04	2E-01/−0.13	2E-02/0.24	2E-01/0.12
C22:6		44	28	7E-04/−0.34	4E-02/−0.22	4E-01/−0.07	1E-01/0.15

This table reports P-value and correlation coefficient of identified subclasses from the 485 features (corresponding to 295 unique lipids) including their fatty acyl side chains, for sex and age effect on two principal components: PC1, PC2. Associations with sex or age which have a P-value < 0.05 are highlighted in bold. For abbreviations of lipid categories and (sub)classes, please refer to Table 1.