Table 3.
Impact of sex and age on the circulating lipidome of 100 healthy individuals as revealed by WGCNA (strategy 3).
| P-value/correlation | |||||||
|---|---|---|---|---|---|---|---|
| PC1 | PC2 | PC1 | PC2 | ||||
| Modules 22 total |
Features # (% identified) |
Predominant Category (%) |
Predominant (Sub)class or FA |
Sex | Age | ||
| M1 | 124 (35%) | GP (23%) | LPC (21%) | 1E-02/0.26 | 3E-01/0.09 | 6E-01/0.05 | 7E-01/0.04 |
| M2 | 70 (20%) | GP (13%) | PC (10%) | 1E-01/0.17 | 2E-01/0.12 | 3E-02/−0.22 | 9E-01/0.01 |
| M3 | 58 (80%) | GL (50%) | TG (43%) | 7E-04/0.34 | 7E-01/0.02 | 6E-01/0.06 | 2E-02/0.23 |
| M4 | 54 (55%) | GP (43%) | C18:2 & C20:4 (39%) | 9E-02/0.19 | 4E-01/0.09 | 4E-03/−0.29 | 3E-01/−0.11 |
| M5 | 49 (63%) | SL (47%) | SM (41%) | 1E-01/−0.17 | 9E-03/−0.27 | 7E-01/−0.03 | 4E-05/0.39 |
| M6 | 46 (59%) | SL (54%) | Cer (50%) | 3E-02/0.21 | 2E-01/0.15 | 7E-02/0.18 | 2E-01/−0.13 |
| M8 | 36 (72%) | GP (67%) | PC (64%) | 7E-01/−0.05 | 2E-01/0.16 | 5E-01/0.07 | 2E-03/−0.31 |
| M9 | 35 (83%) | GP (83%) | LPC & LPE (83%) | 9E-01/0.01 | 4E-02/0.21 | 4E-01/0.08 | 7E-01/−0.04 |
| M10 | 30 (83%) | GP (74%) | C18:2 (67%) | 5E-01/−0.03 | 8E-02/0.18 | 2E-04/−0.37 | 9E-01/0.02 |
| M11 | 30 (70%) | GL (67%) | C18:2 & C20:4 (47%) | 5E-03/0.29 | 2E-01/−0.13 | 6E-01/−0.05 | 8E-03/0.27 |
| M12 | 28 (34%) | GP (61%) | PC & PI (57%) | 2E-01/−0.12 | 1E00/0.02 | 7E-01/−0.03 | 7E-03/0.28 |
| M14 | 27 (55%) | SL (55%) | SM (55%) | 9E-01/−0.04 | 2E-03/−0.32 | 2E-2/0.24 | 2E-01/0.11 |
| M15 | 26 (92%) | GP (86%) | C22:6 (92%) | 8E-03/−0.33 | 8E-02/0.18 | 4E-01/−0.09 | 5E-01/0.06 |
| M16 | 21 (0%) | Unknown | Unknown | 6E-1/0.07 | 3E-02/0.22 | 4E-02/−0.21 | 7E-01/−0.03 |
| M17 | 19 (84%) | GP (79%) | PCO-(79%) | 2E-01/0.14 | 6E-04/0.32 | 6E-02/−0.19 | 1E-02/0.24 |
| M18 | 17 (88%) | GP (88%) | PE (88%) | 7E-02/−0.17 | 9E-03/0.27 | 2E-01/−0.12 | 1E-03/−0.31 |
| M21 | 14 (57%) | FA (57%) | FFA (57%) | 3E-02/−0.23 | 7E-01/0.05 | 1E-02/0.25 | 9E-01/−0.01 |
| M22 | 12 (100%) | SL (100%) | SM (75%) | 8E-01/−0.02 | 3E-02/0.23 | 6E-01/−0.06 | 4E-01/−0.08 |
This table reports P-value and correlation coefficient of the 18 significant modules (P-value <0.05) from the 22 generated by WGCNA. All 18 modules have P-value <0.05 (highlighted in bold) for at least one of the variable tested (sex and age) for one of the two principal components: PC1, PC2. For each module, we report the predominant lipid category, subclass or fatty acyl side chain that was identified.