. 2019 Jun 10;11(2):20. doi: 10.1038/s41368-019-0053-2

Table 3.

Summary of the HDAC class/isoform specificity of commonly used HDACis

HDACi	HDACs targeted	Notes and references
Sodium butyrate	Class I and II	Early pan-HDACi²³⁷
Valproic acid	Class I and II	Early pan-HDACi²³⁷
Trichostatin A	HDAC1, HDAC2, HDAC3, HDAC5, HDAC6 and HDAC7 (or “Class I and Class II”)	Conflicting reports: with a low efficacy to HDAC8 in some studies,²³⁸ or as specific to HDAC1, HDAC3 and HDAC8,²³⁹ or a high level of targeting many Class I and Class II HDACs¹⁹
Romidepsin	Class I	FDA anticancer agent used to treat various lymphomas²³⁷
Entinostat (MS-275)	HDAC1, HDAC2 and HDAC3	Widely reported as an isoform-specific HDACi^237,238
Vorinostat (SAHA)	HDAC1, HDAC2, HDAC3, HDAC6 and possibly HDAC7	Specificity has conflicting reports–some report as Class I, II and IV, others just HDAC1, HDAC2, HDAC3 and HDAC6.¹⁹ Multiple reports of just targetting HDAC7 also reported³⁰