Table 2.

Gene Expression Changed in SC WAT of the Contralateral Leg in lean research participants.

Gene Symbola	Name	Pre	Post	Fold Change Post/Pre	P
VEGFA	Vascular endothelial growth factor A	1312 ± 78	1548 ± 82	1.18	0.006
ANGPT2	Angiopoietin 2	128 ± 9	163 ± 15	1.27	0.007
ANGPT4	Angiopoietin 4	14 ± 1	11 ± 1	0.75	0.009
ANGPT1	Angiopoietin 1	932 ± 84	826 ± 99	0.89	0.014
ANGPTL4	Angiopoietin Like 4	2063 ± 157	1585 ± 177	0.77	0.024
FNDC5	Fibronectin type III domain-containing protein 5	26 ± 3	21 ± 2	0.80	0.034
TPSAB1	Tryptase	2562 ± 318	3172 ± 398	1.24	0.034
IL18	Interleukin-18	80 ± 9	98 ± 10	1.23	0.047
CCL26	Chemokine (C-C motif) ligand 26	13 ± 2	17 ± 2	1.31	0.048
TNFRSF12A	TWEAK receptor	17 ± 2	14 ± 2	0.84	0.050

^aSC WAT was isolated before and after Cold treatment and gene expression determined with the Nanostring nCounter system as described in research design and methods. The data are presented as means (nCounter Counts) ± the standard error of the mean (n = 12; two-tailed, paired student’s t-test).