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. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Diabetologia. 2017 Aug 2;60(10):2052–2065. doi: 10.1007/s00125-017-4379-z

Table 2.

The ‘mitochondrial signature’ of obesity. Identification of 47 proteins of different mitochondrial pathways that are significantly down- or upregulated in skeletal muscle biopsies from obese (O) compared with non-obese (non-O) healthy participants

Protein no. Description log2(O/non-O)
Respiratory chain (ETC)
O96000 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
OS=Homo sapiens GN=NDUFB10 PE=1 SV=3
1.10
Q00325 Phosphate carrier protein, mitochondrial
OS=Homo sapiens GN=SLC25A3 PE=1 SV=2
0.90
Q9H8M1 Coenzyme Q-binding protein COQ10 homologue B, mitochondrial
OS=Homo sapiens GN=COQ10B PE=2 SV=1
0.88
P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
OS=Homo sapiens GN=NDUFV1 PE=1 SV=4
0.84
O43181 NADH dehydrogenase [ubiquinone] iron-sulphur protein 4, mitochondrial
OS=Homo sapiens GN=NDUFS4 PE=1 SV=1
0.72
P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
OS=Homo sapiens GN=SDHA PE=1 SV=2
0.48
P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
OS=Homo sapiens GN=NDUFS1 PE=1 SV=3
0.16
P56556 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
OS=Homo sapiens GN=NDUFA6 PE=1 SV=3
−0.94
ATP synthase subunits
O75947 ATP synthase subunit d, mitochondrial
OS=Homo sapiens GN=ATP5H PE=1 SV=3
0.03
P24539 ATP synthase F(0) complex subunit B1, mitochondrial
OS=Homo sapiens GN=ATP5F1 PE=1 SV=2
0.03
P48047 ATP synthase subunit O, mitochondrial
OS=Homo sapiens GN=ATP5O PE=1 SV=1
−0.20
 F8W0P7 ATP synthase subunit beta, mitochondrial (Fragment)
OS=Homo sapiens GN=ATP5B PE=1 SV=2
−0.31
P25705 ATP synthase subunit alpha, mitochondrial
OS=Homo sapiens GN=ATP5A1 PE=1 SV=1
−0.50
P06576 ATP synthase subunit beta, mitochondrial
OS=Homo sapiens GN=ATP5B PE=1 SV=3
−1.09
O75964 ATP synthase subunit g, mitochondrial
OS=Homo sapiens GN=ATP5L PE=1 SV=3
−1.68
ROS
Q9Y2Q3 Glutathione S-transferase kappa 1
OS=Homo sapiens GN=GSTK1 PE=1 SV=3
1.17
P30044 Peroxiredoxin-5, mitochondrial
OS=Homo sapiens GN=PRDX5 PE=1 SV=4
0.45
 A0A0C4DFU2 Superoxide dismutase
OS=Homo sapiens GN=SOD2 PE=1 SV=1
−0.66
Q9Y6N5 Sulphide:quinone oxidoreductase, mitochondrial
OS=Homo sapiens GN=SQRDL PE=1 SV=1
−1.34
Biogenesis
Q9UJZ1 Stomatin-like protein 2, mitochondrial
OS=Homo sapiens GN=STOML2 PE=1 SV=1
0.67
E5KLJ5 Dynamin-like 120 kDa protein, mitochondrial
OS=Homo sapiens GN=OPA-1 PE=1 SV=1
0.06
Q04837 Single-stranded DNA-binding protein, mitochondrial
OS=Homo sapiens GN=SSBP1 PE=1 SV=1
−0.34
TCA cycle
P07954 Fumarate hydratase, mitochondrial
OS=Homo sapiens GN=FH PE=1 SV=3
1.13
P11498 Pyruvate carboxylase, mitochondrial
OS=Homo sapiens GN=PC PE=1 SV=2
0.95
 A0A087WZN1 Isocitrate dehydrogenase [NAD] subunit, mitochondrial
OS=Homo sapiens GN=IDH3B PE=1 SV=1
0.82
 E9PCR7 2-oxoglutarate dehydrogenase, mitochondrial
OS=Homo sapiens GN=OGDH PE=1 SV=1
−0.54
Lipid metabolism
P49327 Fatty acid synthase
OS=Homo sapiens GN=FASN PE=1 SV=3
1.15
Q9NWU1 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
OS=Homo sapiens GN=OXSM PE=1 SV=1
1.01
 A0A0A0MSE2 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
OS=Homo sapiens GN=HADH PE=1 SV=1
0.80
Q9H845 Acyl-CoA dehydrogenase family member 9, mitochondrial
OS=Homo sapiens GN=ACAD9 PE=1 SV=1
0.40
Q9Y305 Acyl-coenzyme A thioesterase 9, mitochondrial
OS=Homo sapiens GN=ACOT9 PE=1 SV=2
0.24
 E7EX59 Propionyl-CoA carboxylase beta chain, mitochondrial
OS=Homo sapiens GN=PCCB PE=1 SV=1
0.17
Amino acid metabolism
Q02252 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
OS=Homo sapiens GN=ALDH6A1 PE=1 SV=2
0.60
P35914 Hydroxymethylglutaryl-CoA lyase, mitochondrial
OS=Homo sapiens GN=HMGCL PE=1 SV=2
0.33
Q92947 Glutaryl-CoA dehydrogenase, mitochondrial
OS=Homo sapiens GN=GCDH PE=1 SV=1
0.31
P30837 Aldehyde dehydrogenase X, mitochondrial
OS=Homo sapiens GN=ALDH1B1 PE=1 SV=3
−0.90
Mitochondrial translation
Q8IYB8 ATP-dependent RNA helicase SUPV3L1, mitochondrial
OS=Homo sapiens GN=SUPV3L1 PE=1 SV=1
0.78
Q8TCS8 Polyribonucleotide nucleotidyltransferase 1, mitochondrial
OS=Homo sapiens GN=PNPT1 PE=1 SV=2
0.53
P43897 Elongation factor Ts, mitochondrial
OS=Homo sapiens GN=TSFM PE=1 SV=2
0.36
 J3QLS3 28S ribosomal protein S7, mitochondrial
OS=Homo sapiens GN=MRPS7 PE=1 SV=1
0.35
Q9H9J2 39S ribosomal protein L44, mitochondrial
OS=Homo sapiens GN=MRPL44 PE=1 SV=1
0.28
Q9P015 39S ribosomal protein L15, mitochondrial
OS=Homo sapiens GN=MRPL15 PE=1 SV=1
−1.06
P82912 28S ribosomal protein S11, mitochondrial
OS=Homo sapiens GN=MRPS11 PE=1 SV=2
−2.14
Others
Q9H2U2 Inorganic pyrophosphatase 2, mitochondrial
OS=Homo sapiens GN=PPA2 PE=1 SV=2
0.74
Q9HB07 UPF0160 protein MYG1, mitochondrial
OS=Homo sapiens GN=C12orf10 PE=1 SV=2
0.44
Q16822 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
OS=Homo sapiens GN=PCK2 PE=1 SV=3
−1.19
Q5JRX3 Presequence protease, mitochondrial
OS=Homo sapiens GN=PITRM1 PE=1 SV=3
−1.23

OS, organism name; GN, gene name; PE, protein existence; SV, sequence version; TCA, tricarboxylic acid