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. 2019 Jun 14;2:208. doi: 10.1038/s42003-019-0461-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — LIP differentially regulates transcriptome and proteome. a Differentially expressed genes (DEG) by ectopic expression of LIP in Cebpb-ko MEFs compared to control empty vector (EV) with an FDR < 0.05. b 15 most enriched functional clusters (DAVID) of mRNAs downregulated in LIP expressing Cebpb-ko MEFs. c Heat map representation of calculated z-scores for differentially expressed proteins in response to LIP expression in Cebpb-ko MEFs compared to EV control. d 15 most enriched functional clusters (DAVID) of proteins downregulated in LIP expressing Cebpb-ko MEFs. e Heat map representation of calculated z-scores for mRNAs and proteins of the pentose-phosphate-shuttle pathway. f Heat map representation of calculated z-scores for mRNAs and proteins of the glycolysis pathway. g 15 most enriched functional clusters (DAVID) of proteins upregulated in LIP expressing Cebpb-ko MEFs. For panels c, e and f z-scores as the number of standard deviations from the mean are depicted below the heat maps; increased colour intensity (+red/-green for mRNA and +yellow/-blue for protein) represents expression levels that are higher or lower than the mean levels from both conditions relative to the standard deviation associated by the mean