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. 2019 Jun 17;9:8656. doi: 10.1038/s41598-019-45001-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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E7130 showed an anti-CAF effect leading to combinational effect against FaDu xenografts. (a) Effect of the indicated administration on day 1 on the relative tumour volume of FaDu subcutaneous xenografts. The mean relative tumour volume to the volume on day 1 ± s.e.m. is shown (n = 6). (b–e) FaDu xenografts were collected 10 days after the indicated administration. The areas of α-SMA (b–d), Ki67 (d), and tenascin-C (e) were analysed by immunohistochemistry. The data shown are the mean area of α-SMA-positive CAFs (b) or tenascin-C (e) to those of the non-treated group ± s.e.m. (n = 5). (b) **P = 0.0021, ***P = 0.0002, (e) *P = 0.0360, **P = 0.0031 versus the non-treated group (Dunnett’s multiple comparison test). Representative images are shown in (c,d).