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. 2019 Jun 17;10(7):476. doi: 10.1038/s41419-019-1711-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Cytotoxic activities of the meso1 CAR T cells and the meso3 CAR T cells against HGC-27 cells were measured using RTCA system at the E:T ratio of 2:1. b Quantified data on the specific lytic levels of CAR T cells against HGC-27 cells were analyzed at different E:T ratios (mean ± SD; n = 3; one way ANOVA test). c Cytotoxic activities of the meso1 CAR T cells and the meso3 CAR T cells against SKOV-3 cells were measured using RTCA system at the E:T ratio of 2:1. d Quantified data on the specific lytic levels of CAR T cells against SKOV-3 cells were analyzed at different E:T ratios (mean ± SD; n = 3; one way ANOVA test). e The killing activity of meso1 CAR and meso3 CAR T cells was detected using the 3D cancer spheroid model in gastric cancer. f The time effect of death rate of tumor cells was shown by histogram in gastric cancer. g The killing activity of meso1 CAR and meso3 CAR T cells was detected using the 3D cancer spheroid model in ovarian cancer. h The time effect of death rate of tumor cells was shown by histogram in ovarian cancer