Table 1.
Baseline characteristics of subjects undergoing bone marrow aspiration and culture and MRI characteristics.
| Characteristic | Participants (n = 25) |
|---|---|
| Age, years (mean (SD)) | 46.5 (5.3) |
| Females, n (%) | 17 (67) |
| Relapsing remitting course, n (%) | 10 (42) |
| Secondary progressive course, n (%) | 14 (58) |
| Disease duration, years, mean (SD) | 15.1 (9.7) |
| EDSS, median (range) | 6.0 (3.0–6.5) |
| MSFC | |
| T25FW, seconds, mean (SD) | 9.83 (4.85) |
| 9HPT, mean of reciprocals, mean (SD) | 0.04 (0.01) |
| PASAT, n correct, mean (SD) | 45.28 (11.43) |
| Disease modifying treatment | |
| Interferon, n (%) | 6 (25) |
| Glatiramer acetate, n (%) | 7 (29) |
| No Treatment, n (%) | 12 (46) |
| MRI characteristics | |
| Contrast enhancing lesions, n (%) | 6 (25) |
| T2 lesion volume, ml (mean (SD)) | 20.9 (12.2) |
| Brain parenchymal fraction, mean (SD) | 0.776 (0.039) |
| Cortical thickness, mm, mean (SD) | 3.21 (0.24) |
| DTI Metrics | |
| Lesion FA, mean (SD) | 0.347 (0.028) |
| Lesion MD, mean (SD) | 1.017 (0.056) |
| Lesion RD, mean (SD) | 0.820 (0.051) |
| Lesion AD, mean (SD) | 1.409 (0.083) |
| CST FA, mean (SD) | 0.440 (0.031) |
| CST MD, mean (SD) | 0.762 (0.036) |
| CST RD, mean (SD) | 0.566 (0.033) |
| CST AD, mean (SD) | 1.153 (0.063) |
| TCM FA, mean (SD) | 0.444 (0.027) |
| TCM MD, mean (SD) | 0.787 (0.056) |
| TCM RD, mean (SD) | 0.580 (0.054) |
| TCM AD, mean (SD) | 1.202 (0.068) |
MSFC: multiple sclerosis functional composite; T25FW: timed 25-foot walk; 9HPT: 9 hole peg test; PASAT: paced auditory serial addition test; FA: fractional anisotropy; MD: mean diffusivity; RD: radial diffusivity; AD: axial diffusivity; EDSS: Expanded Disability Status Scale; SD: standard deviation; CST: corticospinal tract; TCM: transcallosal motor tract.
DTI metrics (MD, RD, AD) are presented as × 10−3 mm2/s.