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. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Lasers Surg Med. 2018 May 25;50(5):440–450. doi: 10.1002/lsm.22934

Fig. 1.

Fig. 1.

Surgical resection increases systemic and local IL-6. Surgical resection increased serum levels of IL-6 at the conclusion of macroscopic complete resection (MCR) as compared to baseline levels in a clinical trial that includes extended pleurectomy/decortication for treatment of malignant pleural mesothelioma (A). In flank tumors of AB12 murine mesothelioma, surgical resection (SR) increased serum (B) and tumor (C) levels of IL-6 (post-SR) as compared to untreated controls (naϊve tumor). Dots above box plots represent values deemed to be outliers by Tukey test. N = 27 for serum and n = 3−4 human for mouse tumor and serum, except in tumor controls where n = 7−10. *P < 0.05 for comparison to baseline or tumor control.