Table 3.

Validation of the selected circRNAs by qPCR and ROC analysis

CircRNA	Expressiona		AUC	P-value	Sensitivity	Specificity
CRC tissues	Adjacent tissues
has_circ-0004585	8.47±1.34	9.09±1.37	0.731	0.000**	0.851	0.511
hsa_circ_0002568	10.37±2.75	8.27±3.08	0.665	0.021*	0.792	0.523
hsa_circ_0002566	10.62±2.17	7.70±2.20	0.717	0.000**	0.697	0.509
hsa-circ-0002567	10.84±1.76	8.01±2.08	0.726	0.000**	0.875	0.629
hsa-circ-0074033	3.31±2.12	5.84±3.67	0.721	0.002**	0.785	0.607
hsa-circ-0074039	2.56±1.84	4.74±2.79	0.728	0.001**	0.846	0.667

Notes: ^aThe expression of each circRNA was calculated from the ΔCt and expressed as mean±standard deviation; * P<0.05; ** P<0.01.

Abbreviations: AUC, area under the curve; CRC, colorectal cancer; qPCR, quantitative polymerase chain reaction; ROC, receiver operating characteristic.