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. Author manuscript; available in PMC: 2019 Jun 17.
Published in final edited form as: Anal Chem. 2019 Apr 15;91(9):5802–5809. doi: 10.1021/acs.analchem.9b00026

Figure 4.

Figure 4

Results of MCR-ALS analysis of MSI data obtained from Irinotecan treated spheroid (5 μM, 1 h). (A) The spatial distribution patterns and the corresponding ions of (A) component 1 (outer region of spheroid), (B) component 2 (inner region of spheroid), and (C) component 3 (background).