Table 1.
Echocardiographic measurements of TFAM-TG mice at baseline and 8 weeks after sham/TAC surgery
| Baseline | 8-week | |||||||
|---|---|---|---|---|---|---|---|---|
| N=6 | N=7 | N=6 | N=6 | N=6 | N=5 | N=6 | N=5 | |
| Groups | C57 Sham | C57 TAC | TFAM Sham | TFAM TAC | C57 Sham | C57 TAC | TFAM Sham | TFAM TAC |
| IVSd (mm) | 0.65 ± 0.03 | 0.60 ± 0.04 | 0.62 ± 0.02 | 0.61 ± 0.03 | 0.60 ± 0.02 | 0.88 ± 0.02***,### | 0.64 ± 0.02 | 0.79 ± 0.03***,### |
| LVDd (mm) | 3.49 ± 0.15 | 3.57 ± 0.22 | 3.6 ± 0.07 | 3.53 ± 0.14 | 3.58 ± 0.05 | 4.13 ± 0.09*,# | 3.7 ± 0.08 | 3.97 ± 0.12*,# |
| LVPWd (mm) | 0.63 ± 0.02 | 0.67 ± 0.03 | 0.61 ± 0.04 | 0.65 ± 0.01 | 0.64 ± 0.07 | 0.97 ± 0.05**,## | 0.65 ± 0.01 | 0.88 ± 0.09**,## |
| LVDs (mm) | 1.74 ± 0.11 | 1.81 ± 0.08 | 1.85 ± 0.08 | 1.80 ± 0.10 | 1.91 ± 0.15 | 2.98 ± 0.15***,### | 1.94 ± 0.09 | 2.45 ± 0.07***,### |
| LV Vold (ml) | 58.2 ± 5.32 | 61.4 ± 3.88 | 60.9 ± 5.14 | 65.3 ± 3.21 | 63.24 ± 4.06 | 88.6 ± 4.35*,# | 62.05 ± 3.54 | 72.4 ± 3.86*,#,$ |
| LV Vols (ml) | 9.12 ± 0.88 | 10.24 ± 1.56 | 10.12 ± 1.04 | 11.48 ± 2.56 | 10.81 ± 2.09 | 66.54 ± 5.63***,### | 11.12 ± 2.08 | 48.39 ± 4.11**,###,$ |
| EF (%) | 81.7 ± 2.01 | 80.1 ± 1.35 | 82.4 ± 1.21 | 82.8 ± 1.19 | 81.6 ± 1.83 | 48.4 ± 3.69***,### | 80.2 ± 1.85 | 53.1 ± 4.81***,### |
| FS (%) | 48.2 ± 1.58 | 49.4 ± 1.08 | 48.6 ± 1.32 | 49.6 ± 1.78 | 49.5 ± 0.82 | 24.2 ± 1.84***,### | 48.4 ± 0.9 | 28.32 ± 4.64***,### |
| LV mass (mg) | 75.5 ± 4.62 | 78.4 ± 5.51 | 82.4 ± 3.8 | 84.2 ± 4.28 | 81.6 ± 5.6 | 191.6 ± 16.9***,### | 83 ± 4.84 | 164 ± 13.67***,###,$ |
| HR (beats/min) | 640 ± 27 | 690 ± 11.4 | 670 ± 33 | 648 ± 23 | 694 ± 15 | 701 ± 11 | 686 ± 10 | 691 ± 18 |
The table above depicts the echocardiographic measurements after 8 weeks of aortic banding surgery. The groups above signify the following: (1) IVSd, intra-ventricular septal diameter, (2) LVDd, Left ventricular dimension in diastole, (3) LVPWd, left ventricular posterior wall diameter, (4) LVDs, left ventricular dimension in systole, (5) LV Vold, left ventricular volume in diastole, (6) LV Vols, left ventricular volume in systole, (7) EF, ejection fraction, (8) FS, fractional shortening, (9) LV, left ventricular, (10) HR, heart rate
P< 0.001,
P< 0.025,
P<0.05 versus baseline in the same group
P< 0.001,
P< 0.025,
P< 0.05 versus sham in the same group at the same time point
P<0.001,
P<0.025,
P<0.05 versus TAC-operated WT mice. Values are expressed as ±SEM