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Spatial distribution of the infarct produced by transient MCA occlusion in vehicle-treated rats and in rats treated with the COX-2 inhibitor NS-398. In NS-398-treated rats, the lesion is smaller at all rostro-caudal levels. The area “rescued” from infarction involves primarily the medial edge of the lesion and includes the region in which the COX-2-positive neurons are located (cf. Fig. 4)
