Table 1.
Time (hr) | Treatment | Arterial blood gases | Hematocrit (%) | ||
---|---|---|---|---|---|
pH | pCO2 (mmHg) | pO2 (mmHg) | |||
6 | Vehicle | 7.35 ± 0.02 | 41 ± 1 | 86 ± 4 | 49.3 ± 0.9 |
NS-398 | 7.35 ± 0.03 | 40 ± 1 | 83 ± 5 | 49.2 ± 0.5 | |
24 | Vehicle | 7.39 ± 0.03 | 39 ± 2 | 99 ± 4 | 48.3 ± 0.6 |
NS-398 | 7.39 ± 0.03 | 40 ± 1 | 104 ± 5 | 48.5 ± 0.4 | |
48 | Vehicle | 7.37 ± 0.07 | 39 ± 3 | 90 ± 8 | 48.5 ± 0.5 |
NS-398 | 7.33 ± 0.04 | 39 ± 1 | 86 ± 3 | 48.5 ± 0.6 | |
72 | Vehicle | 7.34 ± 0.05 | 41 ± 2 | 88 ± 7 | 48.0 ± 0.9 |
NS-398 | 7.31 ± 0.05 | 44 ± 2 | 90 ± 4 | 48.0 ± 0.7 |
No statistically significant differences were found between rats treated with vehicle or NS-398 (p > 0.05,t test).