Fig. 5.

Effect of ketamine (30 mg/kg) and LY293558 (0.1 and 1.0 mg/kg) on spatial delayed alternation performance in rats. Each animal received 10 trials per day, and the mean ± SEM percentage of correct responses per session is presented. The trials were performed with a delay of 10 sec. The values inparentheses represent the doses in mg/kg. Saline(veh) and LY293558 (LY) were injected 15–20 min before ketamine (ket) in groups designated as veh/ket and LY/ket, respectively. Pretreatment with LY293558 produced a significant reversal of ketamine-induced decrease in percentage of correct choice in saline-treated rats (*p < 0.01, as compared with the veh group, + p < 0.01 as compared with the veh/ket group).