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. 1997 Apr 15;17(8):2921–2927. doi: 10.1523/JNEUROSCI.17-08-02921.1997

Fig. 6.

Fig. 6.

Effect of intraperitoneal pretreatment with saline or LY293558 (1.0 mg/kg) on ketamine (30 mg/kg)-induced increase in dopamine release in the prefrontal cortex. Treatment groups paralleled the behavioral studies depicted on Figure 5. Injections were 20 min apart. Significant increases in dopamine release were observed in both LY293558+ketamine and saline+ketamine group (n = 7,p < 0.01; n = 8, p < 0.01, respectively). However, the increase after LY293558+ketamine was significantly smaller than that observed after saline+ketamine (p < 0.05, as determined by two-way repeated-measures ANOVA).