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Regulation of BDNF mRNA by DOI. Rats were administered vehicle or DOI (8 mg/kg), and levels of BDNF mRNA were determined by in situ hybridization. Representative autoradiographs of sagittal brain sections from vehicle- and DOI-treated groups are shown. Arrowheads indicate the decrease in BDNF expression in the dentate gyrus (DG) and the induction in neocortex (CTX) and claustrum (CL). The induction in BDNF mRNA levels in cortex is widespread and seems to be in specific layers.
