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Regulation of BDNF mRNA by different doses of DOI. Rats were administered vehicle or different doses of DOI from 0.1 to 2.0 mg/kg, and levels of BDNF mRNA were determined by in situ hybridization. Representative autoradiographs from each treatment group are shown. The results are expressed as percent of vehicle and are the mean ± SEM (n = 3–4). *p < 0.05 compared with vehicle (ANOVA; Newmann–Keuls post hoc test).
