Fig. 9.

Influence of ketanserin (KET) on the stress-induced downregulation of BDNF mRNA. Rats were pretreated with vehicle or ketanserin (5 mg/kg) 30 min before being subjected to immobilization stress (2 hr). Levels of BDNF mRNA were determined immediately after stress by in situ hybridization. Representative autoradiographs from the different treatment groups are shown. Results are expressed as percent of vehicle and are the mean ± SEM (n = 12). *p < 0.05 compared with vehicle; **p < 0.05 compared with stress (ANOVA; Newmann–Keuls post hoc test).