Table 1.
Influence of the 5-HT1A agonist 8-OH-DPAT on BDNF mRNA levels in hippocampus and neocortex
| Region | BDNF mRNA (% of vehicle ± SEM) | |
|---|---|---|
| Sham | 8-OH-DPAT | |
| Parietal cortex | 100 ± 7 | 101 ± 4 |
| CA1 | 100 ± 2 | 97 ± 5 |
| CA3 | 100 ± 3 | 98 ± 4 |
| Dentate gyrus | 100 ± 3 | 97 ± 3 |
Rats were administered vehicle or 8-OH-DPAT (1 mg/kg), and levels of BDNF mRNA were determined 2 hr later by in situhybridization analysis. Levels of BDNF mRNA were quantified by densitometry. The results are expressed as percent of vehicle and are the mean ± SEM (n = 4).