Skip to main content
. 1997 Feb 1;17(3):1011–1024. doi: 10.1523/JNEUROSCI.17-03-01011.1997

Fig. 6.

Fig. 6.

Activators of PKC mimic slow responses to 5-HT.A, The phorbol ester PDBu evokes a slow depolarization in AH/type 2 neurons associated with an increase in input resistance, no matter whether it is applied by microejection (1) from a pipette positioned close to the impaled neuron or by superfusion (2) in the ambient medium. Superfusion of PDBu also inhibits the AH (3) that follows the action potential in these cells. Note that although the effects of PDBu are qualitatively similar to those of 5-HT, the response to PDBu is much longer lasting.B, The effects of 5-HT (1.0 μm), OAG (100 μm), and PDBu (1.0 μm) on the amplitude of the AH in AH/type 2 neurons are compared. All three compounds inhibit the AH; PDBu is the most potent.