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. 1997 Feb 1;17(3):1011–1024. doi: 10.1523/JNEUROSCI.17-03-01011.1997

Fig. 7.

Fig. 7.

Inhibitors of PKC antagonize slow responses to 5-HT. A, Slow responses to 5-HT of an AH/type 2 neuron are antagonized by the intracellular injection of the PKC pseudosubstrate PKC[19–31] (top trace,left) and by the superfusion of the membrane permeable PKC pseudosubstrate myr-PKC[19–27] (myr-FARKGALRQ;bottom trace, left). Slow responses are also inhibited by the superfusion of chelerythrine (3.0 μm; top trace, right) and by the selective PKC α and β antagonist Gö 6976 (10 μm; bottom trace,right). B,C, The abilities of PKC[19–31] chelerythrine and K252a to reduce the amplitude of the 5-HT-induced slow depolarization of AH/type 2 cells are compared.