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The decrease in NF proteins in the neocortex of the 6-month-old NFHLacZ transgenic (TG) mice is selective. Whereas there is a decrease in NFM and NFL in the TG mouse, the levels of tubulin (TUB) and synaptophysin (SYN) are not reduced in the same TG mouse compared with the wild-type (WT) mouse. However, elevations in the levels of the microtubule-associated protein 2 (MAP2) and 5 (MAP5) are noted in the same TG mouse.
