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. 1997 Feb 1;17(3):1064–1074. doi: 10.1523/JNEUROSCI.17-03-01064.1997

Fig. 6.

Fig. 6.

Selective loss of Purkinje cells, but not the CA1 neurons of hippocampus, is noted in the aged NFHLacZ (TG) mice compared with age-matched wild-type (WT) mice. Three pairs of age-matched NFHLacZ transgenic and wild-type mice from each age group are examined. The number of Purkinje cells per unit length slightly decreases (∼20%) in the 12-month-old NFHLacZ transgenic mice compared with the age-matched wild-type mice, but a 60% decrease in the number of Purkinje cells/unit length is noted in the 18-month-old NFHLacZ transgenic mice (8 cells/unit length) compared with the age-matched wild-type mice (22 cells/unit length; *p < 0.0001 by Student’s t test) (B). In contrast to the cerebellum, the number of CA1 hippocampal neurons per unit length does not decrease either in the 12-month-old or the 18-month-old mice compared with the age-matched wild-type mice (A).