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Antagonism of DA transport-associated current by cocaine. I–V plots of currents elicited during consecutive applications to a single oocyte of 3 μmcocaine (Coc; - - -), 2 μm DA (——), and 3 μm cocaine plus 2 μm DA (— —). Currents were measured during voltage ramps (−130 to +80 mV in 750 msec), and subtractions all used the IDrug− IControl convention. Comparison of the DAI–V with the DA + Cocaine I–V reveals the transport-associated component that is susceptible to blockade by cocaine.
