Fig. 2.

Nociceptin increases inwardly rectifying K⁺ conductance of PAG neurons. A, Voltage command steps of 250 msec duration were made in 10 mV increments from a holding potential of −60 to −140 mV. The resulting membrane currents in the absence (Control) and presence of nociceptin (Noc 300 nm) in a single neuron are shown. B, The current–voltage relationship for control (○), nociceptin (•), and wash (□) is plotted from the amplitudes of evoked currents shown in A.