Fig. 6.

Nociceptin decreases the frequency, but has no effect on the amplitude, of both mIPSCs and mEPSCs in a subpopulation of PAG neurons. A, mIPSC andB, mEPSC frequency (filled bars) and mean amplitude (open bars) before, during, and after the application of nociceptin (300 nm) for those neurons in which there was a significant increase in inter-event interval (p < 0.05, K–S statistic for control/nociceptin). The pooled results of six neurons for mIPSCs and eight neurons for mEPSCs are shown. Error bars indicate ± SEM.