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Blockade of peptide toxicity with anti-LRP antibody. Chick sympathetic neurons were preincubated for 2 hr with 30 μg/ml either polyclonal anti-LRP or monoclonal anti-apoA1 antibodies and then treated with 2 μg/ml peptide E(141–149)2. Vital dye staining of neuronal cultures revealed that only cultures pretreated with the anti-LRP antibody were protected from peptide toxicity. Error bars indicate mean ± SEM.
