Table 2.

Effects of the ApoE genotype on the loss of subcortical neurons and on dendritic growth in AD

	Control	Alzheimer’s disease
		ApoE 3/3	ApoE 3/4	ApoE 4/4
Basal nucleus of Meynert
Dendritic length (mm)	2.612  ± 0.049	3.600  ± 0.0472-165	3.353  ± 0.0452-165##	3.275  ± 0.0362-165###
Neuronal density (%)	100	36.3  ± 3.82-165	26.6  ± 3.92-165	13.4  ± 2.92-165##
Locus coeruleus
Dendritic length (mm)	2.230  ± 0.041	3.021  ± 0.0312-165	2.838  ± 0.0272-165###	2.732  ± 0.0192-165###
Neuronal density (%)	100	49.9  ± 3.52-165	33.1  ± 5.32-165##	14.2  ± 5.02-165###
Raphe magnus nucleus
Dendritic length (mm)	2.520  ± 0.026	2.982  ± 0.0212-165	2.922  ± 0.0272-165	2.855  ± 0.0292-165###
Neuronal density (%)	100	70.3  ± 2.22-165	62.5  ± 8.52-165	49.1  ± 3.72-165###
Medial amygdaloid nucleus
Dendritic length (mm)	2.342  ± 0.026	2.776  ± 0.0222-165	2.730  ± 0.0282-165	2.654  ± 0.0302-165##
Neuronal density (%)	100	75.1  ± 2.12-165	66.3  ± 2.82-165#	44.1  ± 3.72-165###
Pedunculopontine tegmental nucleus
Dendritic length (mm)	2.410  ± 0.024	2.867  ± 0.0202-165	2.805  ± 0.0322-165	2.733  ± 0.0252-165##
Neuronal density (%)	100	77.7  ± 3.82-165	58.8  ± 3.42-165##	35.4  ± 5.12-165###
Substantia nigra
Dendritic length (mm)	2.155  ± 0.037	2.389  ± 0.0302-165	2.299  ± 0.0272-160	2.256  ± 0.008#
Neuronal density (%)	100	87.8  ± 1.32-165	77.3  ± 2.72-165###	62.6  ± 4.82-165###

Data are mean ± SEM. Significantly different from control:

F2-165: p < 0.001;

F2-160: p < 0.01 (Student’st test). Significantly different from AD subgroup ApoE 3/3: ###p < 0.001; ##p < 0.01; #p < 0.05 (Student’s t test). For group size, see Table 1.