. 1997 Jan 15;17(2):516–529. doi: 10.1523/JNEUROSCI.17-02-00516.1997

Table 5.

Changes in the number of cholinergic neurons in the basal nucleus of Meynert and the activity of ChAT in the cerebral cortex in different subgroups of patients with AD

	Control	Alzheimer’s disease
	Control	ApoE 3/3	ApoE 3/4	ApoE 4/4
Neuronal number
ChAT-immunoreactive	178,467 ± 4230	64,834 ± 4852^5-165	47,519 ± 5115^5-165#	23,850 ± 4635^5-165###
p75^NGFR-immunoreactive	182,389 ± 4820	66,972 ± 5210^5-165	49,608 ± 4864^5-165#	25,160 ± 4645^5-165###
ChAT activity (nmol/mg protein × h)
Brodmann area 8	11.9 ± 0.70	7.14 ± 0.52^5-165	3.33 ± 0.34^5-165###	0.83 ± 0.22^5-165###
Brodmann area 20	8.3 ± 0.40	5.47 ± 0.25^5-165	2.40 ± 0.25^5-165###	0.55 ± 0.05^5-165###

Data are mean values ± SEM; for group size, compare Table1. Significantly different from control:

F5-165: p < 0.001 (Student’s t test). Significantly different from AD subgroup ApoE 3/3: ###p < 0.001; #p< 0.05 (Student’s t test). For group size, see Table1.