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. 1997 Jan 15;17(2):735–744. doi: 10.1523/JNEUROSCI.17-02-00735.1997

Fig. 4.

Fig. 4.

Multiple receptors are involved in μ, α2, and A1 antinociception. A, Clonidine α2 antinociception is blocked not only by yohimbine but also by naloxone and PACPX. Effect of PGE2(E2), clonidine plus PGE2(Cl+E2), yohimbine plus clonidine plus PGE2(Yo+Cl+E2), naloxone plus clonidine plus PGE2 (N+Cl+E2), and PACPX plus clonidine plus PGE2 (PACPX+Cl+E2) on mechanical paw withdrawal threshold in the rat. B, DAMGO μ antinociception is blocked not only by naloxone but also by yohimbine. Effect of PGE2 (E2), DAMGO plus PGE2 (D+E2), naloxone plus DAMGO plus PGE2 (N+D+E2), yohimbine plus DAMGO plus PGE2 (Yo+D+E2), and PACPX plus DAMGO plus PGE2 (PACPX+D+E2) on mechanical paw withdrawal threshold in the rat. C, CPA A1antinociception is blocked not only by PACPX but also by yohimbine. Effect of PGE2 (E2), CPA plus PGE2 (CPA+E2), PACPX plus CPA plus PGE2 (PACPX+CPA+E2), naloxone plus CPA plus PGE2 (N+CPA+E2), and yohimbine plus CPA plus PGE2 (Yo+CPA+E2) on mechanical paw withdrawal threshold in the rat.