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. 1997 Jan 15;17(2):735–744. doi: 10.1523/JNEUROSCI.17-02-00735.1997

Fig. 6.

Fig. 6.

Antisense μ ODN treatment blocks not only μ antinociception but also α2 antinociception. A1 antinociception is unaffected. A, Effect of PGE2 (E2), DAMGO plus PGE2(D+E2), μ-antisense (AS) ODN 1 μg intrathecally on alternate days × 3 and DAMGO plus PGE2 [μ-(AS)x3,D+E2], μ-sense (S) ODN 1 μg intrathecally on alternate days × 3, and DAMGO plus PGE2 [μ-(S)x3,D+E2] on mechanical paw-withdrawal threshold. B, Effect of PGE2 (E2), clonidine plus PGE2(Cl+E2), μ-(AS) ODN 1 μg intrathecally on alternate days × 3, and clonidine plus PGE2[μ-(AS)x3,Cl+E2], μ-(S) ODN 1 μg intrathecally on alternate days × 3, and clonidine plus PGE2[μ-(S)x3,Cl+E2] on mechanical paw-withdrawal threshold. C, Effect of PGE2(E2), CPA plus PGE2 (CPA+E2), μ-(AS) ODN 1 μg intrathecally on alternate days × 3, CPA plus PGE2 [μ-(AS)x3,CPA+E2], μ-(S) ODN 1 μg intrathecally on alternate days × 3, and CPA plus PGE2 [μ-(S)x3,CPA+E2] on mechanical paw withdrawal threshold in the rat.