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. 1997 Jan 15;17(2):796–803. doi: 10.1523/JNEUROSCI.17-02-00796.1997

Fig. 6.

Fig. 6.

The frequency of mIPSCs is decreased by staurosporine (300 nm). The decrease is greater in morphine-withdrawn slices than in controls. A, Experiment from a cell in a slice from a control animal. Top traces show the occurrence of spontaneous IPSCs in control (left) and after superfusion with staurosporine (300 nm, right). The three plots below the traces show an amplitude histogram (left), a cumulative probability plot of the amplitude (middle), and a cumulative probability plot of the frequency of spontaneous IPSCs from the same cell shown above. Staurosporine had little effect on the rate and amplitude of the spontaneous IPSCs.B, Illustration of the same experiment in a cell from a morphine-withdrawn slice. The initial rate of activity was higher, and staurosporine induced a significant decrease in the rate of spontaneous IPSCs (p < 0.05).