Fig. 3.

Recombinant pp60^c-srcpotentiated GABA currents in cultured neurons. A, Intracellular perfusion of the PTK pp60^c-src (30 U/ml, •) potentiated GABA currents in control neurons but not in neurons that had been treated with genistein (100 μm, ○) 10 min before the start of whole-cell recordings.B, Graph of normalized currents recorded in the presence of pp60^c-src alone (n = 4) and pp60^c-src plus genistein (n = 4). Currents were normalized by taking currents recorded at 10 min (I₁₀) over those recorded at 1 min (I₁) after the start of whole-cell recordings. C, I–V relationship constructed from individual currents evoked at holding membrane potentials from −80 to +60 after the potentiation by pp60^c-src has been established.