Fig. 6.

Inhibition of PTKs reduced GABA currents in cells expressing GABA_A receptors consisting of the α1β2 subunits. A, Pharmacological characteristics of GABA-induced currents in a cell transfected with α1β2 subunits. GABA currents were inhibited in a dose-dependent manner by Zn²⁺ but were unaffected by diazepam (5 μm), consistent with the absence of a γ subunit in the functional GABA_A receptors expressed in this cell.B, Application of genistein (50 μm) in the same cell produced a reversible reduction of the amplitude of the GABA currents. Graph on the right represents data from seven individual cells.