Fig. 12.

Recovery of NF-180 expression score is unaffected by blocking axonal regeneration. The NF-180 expression scores of four identified neurons whose axons ordinarily regenerate poorly (≤20%; M₂, M₃, I₁, and Mauthner neurons) and four neurons that always regenerated after a hemisection (100%; neurons M₄, I₄, B₂, and B₆) were averaged 10–13 weeks after a spinal hemisection or amputation (see Materials and Methods). The mean NF-180 expression score remained depressed in neurons that ordinarily regenerate poorly (Poor Regenerators,n = 24–27 neurons), whether regeneration was permitted by spinal hemisection (solid bar) or prevented by spinal cord amputation (dotted bar). Similarly, expression scores recovered in neurons that ordinarily regenerate effectively (Good Regenerators, n = 19–27 neurons), whether regeneration was permitted (solid bar) or prevented (dotted bar). Error bars represent SEM.