Table 1.
Comparison of the properties of α1β1, α1β1ε, and α1β1γ2s GABAA receptors expressed inXenopusoocytes
| α1β1 | α1β1ε | α1β1γ2s | |
|---|---|---|---|
| GABA EC50 | 5.9 ± 1.1 μm (n = 7) | 4.0 ± 1.2 μm (n = 8) | 19.9 ± 4.6 μm (n = 7) |
| Hill slope | 1.32 ± 0.06 | 0.85 ± 0.08 | 1.36 ± 0.18 |
| Mean maximum current (nA) | 1307 ± 224 (n = 13) | 973 ± 78 (n = 15) | 1519 ± 134 (n = 10) |
| Zinc IC50 | 0.24 ± 0.12 μm (n = 4) | 41.9 ± 3.6 μm (n = 4) | 712 ± 296 μm (n = 6) |
| 5α-Pregnan-3α-ol-20-one EC50 | 78 ± 10.9 nm1-b | 194 ± 12 nm | 114 ± 21 nm |
| 5α-Pregnan-3α-ol-20-one potentiation1-a | 265 ± 38% (n = 6) | 260 ± 45 (n = 4) | 214 ± 35 (n = 4) |
F1-a
Maximum potentiation of an EC20 concentration of GABA.
F1-b
Significantly different from α1β1γ2s and α1β1ε, p < 0.05.