Fig. 6.

Activity blockade reduces inhibition onto pyramidal neurons. A, Representative voltage-clamp recordings of spontaneous IPSCs from pyramidal neurons grown in control medium (CONTROL) in medium supplemented with 0.1 μm TTX for 2 d (TTX) or in medium supplemented with TTX and BDNF (25 ng/ml) for 2 d.B, Frequency of spontaneous IPSCs from pyramidal neurons grown under the conditions indicated in A(n = 8 neurons in each condition).C, Total inhibitory current integrated over time, from the same population as in B; *significantly different from control (Student’s t test, p< 0.04); **p < 0.01.