Table 1.

Association of CA1 pyramidal cell intrinsic properties with dendritic spine density

Input resistance	R = −0.50	p < 0.01
Time constant	R = 0.13	p > 0.10
Resting membrane potential	R = 0.36	p < 0.10 trend
mV to threshold	R = 0.25	p> 0.10
Action potential amplitude	R = 0.38	p < 0.10 trend
Action potential duration	R = −0.39	p < 0.10 trend
Afterhyperpolarization amplitude	R = 0.07	p > 0.10
Afterhyperpolarization duration	R = 0.23	p > 0.10

The association of CA1 pyramidal cell intrinsic electrophysiological properties with dendritic spine density was determined by linear regression analysis of each property on spine density for CA1 pyramidal cells. R values and significance levels are shown. A significant negative association between cellular input resistance and dendritic spine density was observed. Additionally, statistical trends toward significant association between spine density and resting membrane potential, action potential amplitude, and action potential duration were detected.