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. 1997 Mar 1;17(5):1670–1682. doi: 10.1523/JNEUROSCI.17-05-01670.1997

Fig. 11.

Fig. 11.

Differential effects of ryanodine on [Ca]i and [Ca]C. Initially, caffeine (5 mm, applied by pressure) caused a larger change in [Ca]i than in [Ca]C (A). After 10–15 min superfusion of 5 μm ryanodine, the baseline fluorescence was not different, the cytosolic response to caffeine was reduced drastically, and [Ca]C was still transiently elevated by caffeine (B). Only 5 min later, and after two to three more responses to caffeine, did [Ca]C response to caffeine attenuate significantly (C).