Fig. 6.

Lipid peroxidation induced by Aβ(25–35) is prevented by melatonin or PBN. The byproduct malondialdehyde acid (MDA) was measured in N2a cell lysates as described (Omar et al., 1987) at the indicated concentrations of melatonin (Fig. 5A), PBN (Fig. 5B), and Aβ(25–35). Values are the means of three determinations. SE in all measurements was <20% of the mean. Cells were exposed to Aβ(25–35) for 24 hr with and without melatonin or PBN.