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. 1997 Mar 1;17(5):1604–1615. doi: 10.1523/JNEUROSCI.17-05-01604.1997

Fig. 10.

Fig. 10.

Models contrasting the proposed roles ford-serine and glycine in developing and adult cerebellum.d-Serine is black; glycine isgray. Stars indicate localizations of NMDA receptors. In developing molecular layer (left), astrocytic d-serine is found in Bergmann glia (BG), which ensheath Purkinje cells expressing NMDA receptors and also guide migrating granule cells (Gr) expressing NMDA receptors. d-Serine released from Bergmann glial processes might synergize with glutamate released by parallel fibers (PF) and climbing fibers (CF). In the developing inner granule layer, protoplasmic astrocytes (Ast) might released-serine near the developing glomerular synapse to synergize with glutamate from mossy fibers (MF), whereas glycinergic basket (Ba) and Golgi neurons (Go) have not yet established connections with NMDA receptor-containing synapses. In contrast, in adult cerebellum (right), no d-serine is present, and NMDA receptors have disappeared from Purkinje cells. NMDA receptor-associated glycine sites located on the basket cell pinceau and granule cells might be modulated exclusively by glycinergic basket (Ba) and Golgi (Go) neurons.