Fig. 3.

Distribution of immunoreactivity for mGluR1 (A), mGluR5 (B), mGluR2/3 (C), and mGluR7a (D) in the hippocampal area corresponding to the rectangle in Figure2C. Immunoreactivity for mGluR1 and mGluR5 is relatively uniform throughout the dentate molecular layer (Mo), whereas that for mGluR2/3 and mGluR7a is prominent in the middle one-third of the layer (mid), which is the terminal zone of the medial perforant path. In the hilus (Hi), dendritic profiles are immunopositive for mGluR1, mGluR5, and mGluR7a, whereas neuropil is immunopositive for mGluR2/3. Dendritic fields (stars) of CA3 pyramidal cells (Py) are immunopositive for mGluR1, mGluR5, and mGluR7a but immunonegative for mGluR2/3. Intense mGluR2/3 labeling is seen in CA1 stratum lacunosum moleculare (LM). The broken lineindicates the hippocampal fissure. Gr, Granule cell layer; in, inner one-third of the molecular layer;out, outer one-third of the molecular layer. Scale bar, 100 μm.