Fig. 7.

Distribution of immunoreactivity for mGluRs in the ipsilateral (A–C, E, G) and contralateral (D, F, H) hippocampus on the seventh day after placing a massive unilateral lesion in the perforant path. Adjacent horizontal sections were reacted with antibodies to mGluR1 (A), mGluR5 (B), mGluR2/3 (C, D), mGluR7a (E, F), and mGluR8 (G, H). The lesion (asterisks) involves the entorhinal cortex and subiculum. Marked reduction of immunoreactivity for mGluR2/3 (C), mGluR7a (E), and mGluR8 (G) is observed in the ipsilateral perforant path terminal zones of the CA areas, i.e., stratum lacunosum moleculare (arrowheads inE) and the molecular layer of the dentate gyrus (DG). No apparent changes are found in immunoreactivity for mGluR1 or mGluR5 (A, B). An mGluR2/3 immunoreactive area remains (arrow in C) in CA1 stratum lacunosum moleculare near CA1–CA2 transition. ipsi, Ipsilateral to the lesion; contra, contralateral to the lesion. Scale bar, 500 μm.