Table 1.
Distribution of immunoreactivity for presynaptic mGluRs in excitatory pathways in the hippocampus
| Subtype | PP (CA1) | PP (CA3) | PP (DG) | MF | A/C (CA3) | Sch |
|---|---|---|---|---|---|---|
| mGluR2 | +++ | ++(medial) | ++(medial) | ++ | − | − |
| mGluR7a | ++ | +++(medial) | ++(medial) | +1-a | ++ | ++ |
| ++(lateral) | +(lateral) | |||||
| mGluR7b | − | − | − | ++1-a | − | − |
| mGluR8 | − | +(lateral) | +(lateral) | − | − | − |
Immunoreactivity: +++, very strong; ++, strong; + moderate to weak; −, very weak, if any. A/C, Associational and commissural fibers; MF, mossy fiber; PP, perforant path; Sch, Schaffer collateral. Medial, lateral: prominent in medial or lateral perforant path terminal zone.
F1-a
Immunoreactivity is mostly present in synapses on interneurons.