Fig. 1.

Alignment of Pdx1 hexapeptide and homeodomain sequence across vertebrates. The human and mouse amino acid sequence, conserved in most vertebrates, is shown at the top. The three alpha helices are labeled, and key amino acids known to directly interact with DNA bases are highlighted with a star (Longo et al. 2007). Lysine/Arginine residues key to the current research are shown for all species. For other residues, only those that deviate from the conserved sequence are shown.